Quantification of endothelial cell-targeted anti-Bcl-2 therapy and its suppression of tumor growth and vascularization.

@article{Jain2009QuantificationOE,
  title={Quantification of endothelial cell-targeted anti-Bcl-2 therapy and its suppression of tumor growth and vascularization.},
  author={Harsh Vardhan Jain and Jacques Eduardo N{\"o}r and Trachette L. Jackson},
  journal={Molecular cancer therapeutics},
  year={2009},
  volume={8 10},
  pages={2926-36}
}
Proapoptotic and antiapoptotic proteins in the Bcl family are key regulators of programmed cell death. It is the interaction between these molecules that determines cellular response to apoptotic signals, making them attractive targets for therapeutic intervention. In recent experiments designed to study tumor angiogenesis, Bcl-2 upregulation in endothelial cells was shown to be a critical mediator of vascular development. In this article, we develop a mathematical model that explicitly… CONTINUE READING

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