Quantification of endogenous carcinogens. The ethylene oxide paradox.

  title={Quantification of endogenous carcinogens. The ethylene oxide paradox.},
  author={Hermann Maximillian Bolt},
  journal={Biochemical pharmacology},
  volume={52 1},
Although ethylene oxide is a proven genotoxic carcinogen in experimental animals, its human carcinogenicity is still being debated. Alkylations (hydroxyethylation) of DNA and proteins by ethylene oxide are well established. Ethylene oxide is metabolically formed from ethylene, which is a natural body constituent. Thus, endogenous sources of ethylene/ethylene oxide contribute to background alkylations of physiological macromolecules. There are now experimentally well established data sets on the… CONTINUE READING

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