Quantification of electrochemically generated iodine-containing metabolites using inductively coupled plasma mass spectrometry.

@article{Lohmann2008QuantificationOE,
  title={Quantification of electrochemically generated iodine-containing metabolites using inductively coupled plasma mass spectrometry.},
  author={Wiebke Lohmann and Bj{\"o}rn Meermann and Ines Moeller and Andy Scheffer and Uwe Karst},
  journal={Analytical chemistry},
  year={2008},
  volume={80 24},
  pages={9769-75}
}
For the risk assessment of drug candidates, the identification and quantification of their metabolites is required. The majority of analytical techniques is based on calibration standards for quantification of the metabolites. As these often are not readily available, the use of inductively coupled plasma mass spectrometry (ICPMS) is an attractive alternative for drugs containing heteroatoms. In this work, the online coupling of electrochemistry (EC), liquid chromatography (LC), and ICPMS is… CONTINUE READING