Quantification of doxorubicin-induced interstitial myocardial fibrosis in a beagle model using equilibrium contrast-enhanced computed tomography: A comparative study with cardiac magnetic resonance T1-mapping.

@article{Zhou2019QuantificationOD,
  title={Quantification of doxorubicin-induced interstitial myocardial fibrosis in a beagle model using equilibrium contrast-enhanced computed tomography: A comparative study with cardiac magnetic resonance T1-mapping.},
  author={Zhen Zhou and Lei Xu and Rui Wang and Akos Varga-Szemes and James A Durden and U. Joseph Schoepf and Zhonghua Sun and Zhanming Fan},
  journal={International journal of cardiology},
  year={2019},
  volume={281},
  pages={
          150-155
        }
}
BACKGROUND The noninvasive equilibrium contrast-enhanced cardiac computed tomography (CCT) has potential for myocardial tissue characterization. The objective of this study was to test the feasibility of CCT-based extracellular volume (ECV) fraction in beagle models of doxorubicin-induced interstitial myocardial fibrosis, with cardiac magnetic resonance (CMR) as the reference. METHODS This study was approved by local ethics committee. Thirteen beagles were included with ECV quantified by CCT… CONTINUE READING