Quantification of dopamine transporter in human brain using PET with 18F-FE-PE2I.

  title={Quantification of dopamine transporter in human brain using PET with 18F-FE-PE2I.},
  author={Takeshi Sasaki and Hiroshi Ito and Yasuyuki Kimura and Ryosuke Arakawa and Harumasa Takano and Chie Seki and Fumitoshi Kodaka and Saori Fujie and Keisuke Takahata and Tsuyoshi Nogami and Masayuki Suzuki and Hironobu Fujiwara and Hidehiko Takahashi and Ryuji Nakao and Toshimitsu Fukumura and Andrea Varrone and Christer Halldin and Toru Nishikawa and Tetsuya Suhara},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  volume={53 7},
UNLABELLED (18)F-(E)-N-(3-iodoprop-2E-enyl)-2β-carbofluoroethoxy-3β-(4-methylphenyl)nortropane ((18)F-FE-PE2I) is a new PET radioligand with a high affinity and selectivity for the dopamine transporter (DAT). In nonhuman primates, (18)F-FE-PE2I showed faster kinetics and less production of radiometabolites that could potentially permeate the blood-brain barrier than did (11)C-PE2I. The aims of this study were to examine the quantification of DAT using (18)F-FE-PE2I and to assess the effect of… CONTINUE READING
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