Quantification of dopamine transporter binding using [18F]FP-beta-CIT and positron emission tomography.

  title={Quantification of dopamine transporter binding using [18F]FP-beta-CIT and positron emission tomography.},
  author={Maqsood Yaqub and Ronald Boellaard and Bart N. M. van Berckel and Mirthe M Ponsen and Mark Lubberink and Albert D. Windhorst and Henk W. Berendse and Adriaan A. Lammertsma},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  volume={27 7},
The purpose of this study was to compare different kinetic and semi-quantitative methods for analysing human [18F]FP-beta-CIT studies: plasma input models, simplified (SRTM) and full (FRTM) reference tissue models, standard uptake values (SUV) and SUV ratios (SUVr). Both simulations and clinical evaluations were performed to determine the effects of noise, scan duration and blood volume on Akaike model selection, and on precision and accuracy of estimated parameters. For typical noise levels… CONTINUE READING