Quantification of cerebral blood flow, cerebral blood volume, and blood-brain-barrier leakage with DCE-MRI.

@article{Sourbron2009QuantificationOC,
  title={Quantification of cerebral blood flow, cerebral blood volume, and blood-brain-barrier leakage with DCE-MRI.},
  author={Steven P. Sourbron and Michael Ingrisch and Axel Siefert and Maximilian Reiser and Karin Herrmann},
  journal={Magnetic resonance in medicine},
  year={2009},
  volume={62 1},
  pages={205-17}
}
Dynamic susceptibility contrast MRI (DSC-MRI) is the current standard for the measurement of Cerebral Blood Flow (CBF) and Cerebral Blood Volume (CBV), but it is not suitable for the measurement of Extraction Flow (EF) and may not allow for absolute quantification. The objective of this study was to develop and evaluate a methodology to measure CBF, CBV, and EF from T1-weighted dynamic contrast-enhanced MRI (DCE-MRI). A two-compartment modeling approach was developed, which applies both to… CONTINUE READING

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