Quantification of cartilage oligomeric matrix protein (COMP) and a COMP neoepitope in synovial fluid of patients with different joint disorders by novel automated assays.

@article{Lorenzo2017QuantificationOC,
  title={Quantification of cartilage oligomeric matrix protein (COMP) and a COMP neoepitope in synovial fluid of patients with different joint disorders by novel automated assays.},
  author={Pilar Hern{\'a}ndez Lorenzo and Anders Aspberg and Tore Saxne and Patrik {\"O}nnerfjord},
  journal={Osteoarthritis and cartilage},
  year={2017},
  volume={25 9},
  pages={1436-1442}
}
OBJECTIVE To develop automated immunoassays for the quantification of Cartilage Oligomeric Matrix Protein (COMP) and a COMP neoepitope in synovial fluid and to investigate their diagnostic potential in different joint conditions. METHODS Two sandwich immunoassays were developed for the quantification of COMP and a COMP neoepitope, using an automated analyser (IDS-iSYS, Immunodiagnostic Systems, Boldon, UK). Assay performance was evaluated in terms of sensitivity, recovery, linearity, and… CONTINUE READING

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