Quantification of brain mu-opioid receptors with [11C]carfentanil: reference-tissue methods.

@article{Endres2003QuantificationOB,
  title={Quantification of brain mu-opioid receptors with [11C]carfentanil: reference-tissue methods.},
  author={Christopher J. Endres and Badreddine Bencherif and John Hilton and Igal Madar and James Frost},
  journal={Nuclear medicine and biology},
  year={2003},
  volume={30 2},
  pages={177-86}
}
[(11)C]Carfentanil (CFN) is a mu-opioid agonist used for in vivo positron emission tomography (PET) studies of mu-opioid receptors. Previously, a tissue-ratio method was validated for the quantification of CFN binding. However, since that initial validation, several other blood independent (reference-tissue) methods have become available. To evaluate these methods, CFN PET studies with arterial blood sampling were acquired in six healthy male control subjects. Specific binding estimates… CONTINUE READING

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