Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe

@article{Champy2005QuantificationOA,
  title={Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe},
  author={Pierre Champy and Alice Melot and Vincent Gu{\'e}rineau Eng and Christophe Gleye and Djibril Fall and G{\"u}nter U. H{\"o}glinger and Merle Ruberg and Annie Lannuzel and Olivier Lapr{\'e}vote and Alain Laurens and Reynald Hocquemiller},
  journal={Movement Disorders},
  year={2005},
  volume={20}
}
Atypical parkinsonism in Guadeloupe has been associated with the consumption of fruit and infusions or decoctions prepared from leaves of Annona muricata L. (Annonaceae), which contains annonaceous acetogenins, lipophilic inhibitors of complex I of the mitochondrial respiratory chain. We have determined the concentrations of annonacin, the major acetogenin in A. muricata, in extracts of fruit and leaves by matrix‐assisted laser desorption‐ionization mass spectrometry. An average fruit is… 
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The fruit of Annona squamosa L. as a source of environmental neurotoxins: From quantification of squamocin to annotation of Annonaceous acetogenins by LC-MS/MS analysis.
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It is demonstrated that the intake of dietary supplements containing plant material from Annonaceae may be hazardous to health in terms of neurotoxicity and neuronal toxicities of these supplements were found.
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TLDR
In Guadeloupe, epidemiological data have linked atypical parkinsonism with fruit and herbal teas from plants of the Annonaceae family, particularly Annona muricata, and these plants contain a class of powerful, lipophilic complex I inhibitors, the annonaceous acetogenins, which support the hypothesis that some forms of parkinsonist might be induced by environmental toxins.
Toxicity of Annonaceae for dopaminergic neurons: Potential role in atypical parkinsonism in Guadeloupe
TLDR
Alkaloids from A. muricata can modulate the function and the survival of dopaminergic nerve cells in vitro, and it is suggested that repeated consumption could cause the neuronal dysfunction and degeneration underlying the West Indian parkinsonian syndrome.
The mitochondrial complex i inhibitor annonacin is toxic to mesencephalic dopaminergic neurons by impairment of energy metabolism
TLDR
This study demonstrates that annonacin promotes dopaminergic neuronal death by impairment of energy production and underlines the need to address its possible role in the etiology of some atypical forms of Parkinsonism in Guadeloupe.
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TLDR
Two new Annonaceous acetogenins showed significant cytotoxicities among six human tumor cell lines with selectivities to the prostate adenocarcinoma and pancreatic carcinoma cell lines.
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TLDR
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