Quantification of TSPO overexpression in a rat model of local neuroinflammation induced by intracerebral injection of LPS by the use of [18F]DPA-714 PET

@article{Ory2015QuantificationOT,
  title={Quantification of TSPO overexpression in a rat model of local neuroinflammation induced by intracerebral injection of LPS by the use of [18F]DPA-714 PET},
  author={Dieter Ory and Andrey Postnov and Michel Koole and Sofie Celen and Bart de Laat and Alfons Verbruggen and Koen Van Laere and Guy Bormans and Cindy Casteels},
  journal={European Journal of Nuclear Medicine and Molecular Imaging},
  year={2015},
  volume={43},
  pages={163-172}
}
[18F]DPA-714 is a radiotracer with high affinity for TSPO. We have characterized the kinetics of [18F]DPA-714 in rat brain and evaluated its ability to quantify TSPO expression with PET using a neuroinflammation model induced by unilateral intracerebral injection of lipopolysaccharide (LPS). Dynamic small-animal PET scans with [18F]DPA-714 were performed in Wistar rats on a FOCUS-220 system for up to 3 h. Both plasma and perfused brain homogenates were analysed using HPLC to quantify… CONTINUE READING

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