Quantification of Neuroreceptors in the living human brain. II. Inhibition studies of receptor density and affinity.

@article{Wong1986QuantificationON,
  title={Quantification of Neuroreceptors in the living human brain. II. Inhibition studies of receptor density and affinity.},
  author={D. F. Wong and Albert Gjedde and Henry N. Wagner and Robert F. Dannals and Kenneth H. Douglass and Jonathan M. Links and Michael Kuhar},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={1986},
  volume={6 2},
  pages={147-53}
}
A method for estimating receptor density (Bmax) in the living human brain by positron emission tomography was exemplified by a ligand, 3-N-[11C]methylspiperone ([11C]NMSP), that binds to D2 dopamine receptors with high affinity. The ligand binds essentially irreversibly (i.e., with very little dissociation) to the receptors during the 2-h scanning period. Transfer constants were estimated at steady state. In a previous article, we presented a method for the determination of k3, the rate of… CONTINUE READING

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