Quantification of MYCN, DDX1, and NAG Gene Copy Number in Neuroblastoma Using a Real-Time Quantitative PCR Assay

@article{Preter2002QuantificationOM,
  title={Quantification of MYCN, DDX1, and NAG Gene Copy Number in Neuroblastoma Using a Real-Time Quantitative PCR Assay},
  author={Katleen De Preter and Frank Speleman and Valerie Combaret and John Lunec and Genevi{\'e}ve Laureys and Bert H J Eussen and Nadine Francotte and Julian R Board and Andy D. J. Pearson and Anne De Paepe and Nadine van Roy and Jo Vandesompele},
  journal={Modern Pathology},
  year={2002},
  volume={15},
  pages={159-166}
}
Amplification of the proto-oncogene MYCN is a strong adverse prognostic factor in neuroblastoma patients in all tumor stages. The status of the MYCN gene has become an important factor in clinical decision making and therapy stratification. Consequently, fast and accurate assessment of MYCN gene copy number is of the utmost importance and the use of two independent methods to determine MYCN status is recommended. For these reasons we have developed and evaluated a real-time quantitative PCR (Q… CONTINUE READING
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1 Excerpt

Multicentre analysis of patterns of DNA gains and losses in 204 neuroblastoma tumors : How many genetic subgroups are there ?

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Multicentre analysis of patterns of DNA gains and losses in 204 neuroblastoma tumors: How many genetic subgroups are there? Med Pediatr Oncol 2001;36:5–10

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2 Excerpts

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