Quantification of Ligand Binding to G-Protein Coupled Receptors on Cell Membranes by Ellipsometry


G-protein-coupled receptors (GPCRs) are prime drug targets and targeted by approximately 60% of current therapeutic drugs such as β-blockers, antipsychotics and analgesics. However, no biophysical methods are available to quantify their interactions with ligand binding in a native environment. Here, we use ellipsometry to quantify specific interactions of… (More)
DOI: 10.1371/journal.pone.0046221

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