Quantification of DNA adducts in lungs, liver and brain of rats exposed to acetaldehyde.

  title={Quantification of DNA adducts in lungs, liver and brain of rats exposed to acetaldehyde.},
  author={Camila Carri{\~a}o Machado Garcia and Guilherme Lopes Batista and Flor{\^e}ncio Porto Freitas and Fernando Silva Lopes and Ang{\'e}lica B. Sanchez and Ivano Gebhardt Rolf Gutz and Paolo Di Mascio and Marisa H G Medeiros},
  journal={Free radical biology \& medicine},
  volume={75 Suppl 1},
Air pollution is a major risk for human health. Acetaldehyde is an environmental pollutant present in tobacco smoke, vehicle exhaust and several food products. Formation of DNA adducts has been regarded as a critical factor in the mechanisms of acetaldehyde mutagenicity and carcinogenesis. Acetaldehyde reacts with 2'-deoxyguanosine in DNA to primarily form N(2)-ethylidene-2'-deoxyguanosine (N(2)-ethylidene-dGuo). The subsequent reaction of N(2)-ethylidene-dGuo with another molecule of… Expand
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