Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages.

@article{Lee1999QuantificationOC,
  title={Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages.},
  author={Betsy Lee and Matthew Sharron and Luis J Montaner and Drew Weissman and Robert W. Doms},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 9},
  pages={
          5215-20
        }
}
CCR5 and CXCR4 are the major HIV-1 coreceptors for R5 and X4 HIV-1 strains, respectively, and a threshold number of CD4 and chemokine receptor molecules is required to support virus infection. Therefore, we used a quantitative fluorescence-activated cell sorting assay to determine the number of CD4, CCR5, and CXCR4 antibody-binding sites (ABS) on various T cell lines, T cell subsets, peripheral blood dendritic cells (PBDC), and monocyte-derived macrophages by using four-color fluorescence… CONTINUE READING
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