Quantification of Bax and Bcl2 in polymorphonuclear leukocytes from haemodialysis patients: relation to hydrogen peroxide.

@article{Perianayagam2003QuantificationOB,
  title={Quantification of Bax and Bcl2 in polymorphonuclear leukocytes from haemodialysis patients: relation to hydrogen peroxide.},
  author={Mary C. Perianayagam and Vaidyanathapuram S Balakrishnan and Daqing Guo and Brian J. G. Pereira and Bertrand L. Jaber},
  journal={European journal of clinical investigation},
  year={2003},
  volume={33 10},
  pages={905-11}
}
BACKGROUND Bax and Bcl2 are two apoptosis-related molecules that play an important role in determining cell fate following oxidative injury. In the present study, we explored the relation of hydrogen peroxide (H2O2) generation by polymorphonuclear cells (PMNs) to the cytosolic expression of Bax and Bcl2 proteins and apoptosis in haemodialysis (HD) patients. METHODS Cytosolic generation of H2O2 by PMNs from control subjects and HD patients was measured by flow cytometry using the… CONTINUE READING

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