Quantification by flow cytometry of the efficacy of and interindividual variation of platelet inhibition induced by treatment with tirofiban and abciximab.

@article{Holmes2001QuantificationBF,
  title={Quantification by flow cytometry of the efficacy of and interindividual variation of platelet inhibition induced by treatment with tirofiban and abciximab.},
  author={Maria Holmes and Samer S. Kabbani and Christopher M Terrien and Matthew W. Watkins and B. E. Sobel and David J. Schneider},
  journal={Coronary artery disease},
  year={2001},
  volume={12 3},
  pages={245-53}
}
BACKGROUND After exposure of platelets to abciximab and tirofiban in vitro, we have observed variable inhibition of fibrinogen binding and a lack of inhibition of alpha-granule degranulation. DESIGN To determine whether such changes occur with treatment, platelet reactivity was assayed in blood from 50 patients receiving abciximab or tirofiban. METHODS Platelet reactivity was determined before and during steady-state infusions of abciximab (0.125 microg/kg/min) or tirofiban, with either the… CONTINUE READING