Quantification and regulation of adipsin in human cerebrospinal fluid (CSF)

  title={Quantification and regulation of adipsin in human cerebrospinal fluid (CSF)},
  author={Andreas Schmid and Alexandra Hochberg and Martin Berghoff and Jutta Schlegel and T. Karrasch and Manfred Kaps and Andreas Schäffler},
  journal={Clinical Endocrinology},
Data on quantification and regulation of adipsin in human cerebrospinal fluid (CSF) are sparse, and the physiological role of adipsin as an adipokine crossing the blood–brain barrier (BBB) is uncertain. 
Systematic Quantification of Neurotrophic Adipokines RBP4, PEDF, and Clusterin in Human Cerebrospinal Fluid and Serum.
RBP4 represents an inflammatory neurotrophic adipokine and is a promising mediator of the fat-brain axis and RBP4 and PEDF serum levels correlated positively with CSF levels, which were increased in overweight/obese patients and in type 2 diabetic patients.
CSF concentrations of adipsin and adiponectin in patients with amyotrophic lateral sclerosis
Adipsin was significantly elevated in CSF, suggesting that this chemokine might have a role in ALS pathogenesis, and adiponectin showed a trend towards higher concentrations, but failed to reach statistical significance.
CTRP‐3 is permeable to the blood–brain barrier and is not regulated by glucose or lipids in vivo
C1q/TNF‐related protein‐3 (CTRP‐3) represents a novel anti‐inflammatory and antidiabetic adipokine secreted by adipose tissue and its expression was investigated in adipocytes upon stimulation with glucose, sex hormones and a broad panel of fatty acids.
An MRM-Based Multiplexed Quantification Assay for Human Adipokines and Apolipoproteins
This multiplexed assay facilitated the investigation of relationships between adipokines or apolipoproteins and phenotypes or clinical parameters in large cohorts, which may contribute to disease prediction approaches in the future.
Multiple Sclerosis: Implications of Obesity in Neuroinflammation.
The "low-grade inflammation" that characterizes obesity can lead to neuroinflammation through different mechanisms, including choroid plexus and blood-brain barrier disruption, which can contribute to increase disease severity by negatively influencing disease progress.
Plasma levels of adipokines in patients with Alzheimer's disease - where is the "breaking point" in Alzheimer's disease pathogenesis?
A correlation of impaired neuropsychological performance with increasing adiponectin and decreasing leptin in AD patients is found and the cause of the adipokine "breaking point" that leads to the pathogenesis of overt AD is explained.
Association between serum adipsin and plaque vulnerability determined by optical coherence tomography in patients with coronary artery disease.
It is suggested that serum adipsin is significantly and positively correlated with the incidence of TCFAs and may offer improvement in the diagnosis of vulnerable plaques and clinical benefits for CAD patients.
Multiple Sclerosis and Obesity: Possible Roles of Adipokines
The main cells involved in MS pathogenesis are described, both from neural tissue and from the immune system, and including a new participant, the adipocyte, focusing on their roles in MS.
Comparison of the Hypoproteinemic Capacities of Erythropoietin and U-74389G
The outcome of the co-evaluation was that U-74389G has at least 4-fold hypoproteinemic action than Epo (p-value=0.0000).
Diagnostic, Prognostic, and Mechanistic Biomarkers of Diabetes Mellitus-Associated Cognitive Decline
Given the skyrocketing global rates of diabetes and neurodegenerative disorders, there is an urgent need to discover novel biomarkers relevant to the co-morbidity of both conditions to guide future diagnostic approaches.


Quantification and regulation of the adipokines resistin and progranulin in human cerebrospinal fluid
Adipokines bearing the potential to cross the blood–brain barrier (BBB) are promising candidates for the endocrine regulation of central nervous processes and of a postulated fat‐brain axis. Resistin
Elevated cerebrospinal fluid adiponectin and adipsin levels in patients with multiple sclerosis: a Finnish co‐twin study
Investigation of the levels of three adipocytokines, leptin, adiponectin and adipsin, in serum and cerebrospinal fluid of twins discordant for multiple sclerosis found them to have a role in various autoimmune disorders including MS.
The acylation stimulating protein-adipsin system.
  • K. Cianflone, M. Maslowska, A. Sniderman
  • Biology, Computer Science
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity
  • 1995
Acylation stimulating protein (ASP), a human plasma protein, stimulates triacylglycerol synthesis in adipose tissue and is also produced by human adipocytes, and may play a physiological role in the regulation of efficiency of adiposes tissue fat storage and affect clearance of triglycerides from plasma.
Adipsin and complement factor D activity: an immune-related defect in obesity
It is suggested that adipsin and the alternative pathway of complement may play an unexpected but important role in the regulation of systemic energy balance in vivo.
Adipokines: inflammation and the pleiotropic role of white adipose tissue
It is suggested that the term ‘adipokine’ be universally adopted to describe a protein that is secreted from (and synthesised by) adipocytes, excluding signals released only by the other cell types (such as macrophages) in adipose tissue.
The adipose tissue as a source of vasoactive factors.
  • G. Frühbeck
  • Biology, Medicine
    Current medicinal chemistry. Cardiovascular and hematological agents
  • 2004
Since blood vessels express receptors for most of the adipocyte-derived factors, adipose tissue seems to play a key role in cardiovascular physiology through the existence of a network of local and systemic signals.
The blood-brain barrier as a cause of obesity.
  • W. Banks
  • Biology
    Current pharmaceutical design
  • 2008
It is postulate that hypertriglyceridemia evolved as a starvation signal to the brain that acts in part to inhibit the transport of the leptin across the blood-brain barrier and providing a mechanism for peripheral leptin resistance.
Adipocytokine Levels in Obese and Non-obese Subjects: an Observational Study
Obese subjects’ predisposition to develop dysmetabolic disease and hormonal dysfunctions is confirmed and higher HOMA index correlated with higher resistin, adipsin, RBP-4, and leptin concentrations, while higher leptin levels correlation with higher TNF-α, Hs-CRP, and IL-6 concentration, and lower ADN values.