Quantification and regulation of adipsin in human cerebrospinal fluid (CSF)

@article{Schmid2016QuantificationAR,
  title={Quantification and regulation of adipsin in human cerebrospinal fluid (CSF)},
  author={Andreas Schmid and Alexandra Hochberg and Martin Berghoff and Jutta Schlegel and T. Karrasch and Manfred Kaps and Andreas Schäffler},
  journal={Clinical Endocrinology},
  year={2016},
  volume={84}
}
Data on quantification and regulation of adipsin in human cerebrospinal fluid (CSF) are sparse, and the physiological role of adipsin as an adipokine crossing the blood–brain barrier (BBB) is uncertain. 
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References

SHOWING 1-10 OF 30 REFERENCES
Quantification and regulation of the adipokines resistin and progranulin in human cerebrospinal fluid
Adipokines bearing the potential to cross the blood–brain barrier (BBB) are promising candidates for the endocrine regulation of central nervous processes and of a postulated fat‐brain axis. Resistin
Elevated cerebrospinal fluid adiponectin and adipsin levels in patients with multiple sclerosis: a Finnish co‐twin study
TLDR
Investigation of the levels of three adipocytokines, leptin, adiponectin and adipsin, in serum and cerebrospinal fluid of twins discordant for multiple sclerosis found them to have a role in various autoimmune disorders including MS.
The acylation stimulating protein-adipsin system.
  • K. Cianflone, M. Maslowska, A. Sniderman
  • Biology, Computer Science
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity
  • 1995
TLDR
Acylation stimulating protein (ASP), a human plasma protein, stimulates triacylglycerol synthesis in adipose tissue and is also produced by human adipocytes, and may play a physiological role in the regulation of efficiency of adiposes tissue fat storage and affect clearance of triglycerides from plasma.
Adipsin and complement factor D activity: an immune-related defect in obesity
TLDR
It is suggested that adipsin and the alternative pathway of complement may play an unexpected but important role in the regulation of systemic energy balance in vivo.
Adipokines: inflammation and the pleiotropic role of white adipose tissue
TLDR
It is suggested that the term ‘adipokine’ be universally adopted to describe a protein that is secreted from (and synthesised by) adipocytes, excluding signals released only by the other cell types (such as macrophages) in adipose tissue.
The adipose tissue as a source of vasoactive factors.
  • G. Frühbeck
  • Biology, Medicine
    Current medicinal chemistry. Cardiovascular and hematological agents
  • 2004
TLDR
Since blood vessels express receptors for most of the adipocyte-derived factors, adipose tissue seems to play a key role in cardiovascular physiology through the existence of a network of local and systemic signals.
The blood-brain barrier as a cause of obesity.
  • W. Banks
  • Biology
    Current pharmaceutical design
  • 2008
TLDR
It is postulate that hypertriglyceridemia evolved as a starvation signal to the brain that acts in part to inhibit the transport of the leptin across the blood-brain barrier and providing a mechanism for peripheral leptin resistance.
Adipocytokine Levels in Obese and Non-obese Subjects: an Observational Study
TLDR
Obese subjects’ predisposition to develop dysmetabolic disease and hormonal dysfunctions is confirmed and higher HOMA index correlated with higher resistin, adipsin, RBP-4, and leptin concentrations, while higher leptin levels correlation with higher TNF-α, Hs-CRP, and IL-6 concentration, and lower ADN values.
...
...