Quantifiable predictive features define epitope-specific T cell receptor repertoires

@article{Dash2017QuantifiablePF,
  title={Quantifiable predictive features define epitope-specific T cell receptor repertoires},
  author={Pradyot Dash and Andrew J. Fiore-Gartland and Tomer Hertz and George C. Wang and Shalini Sharma and Aisha Souquette and Jeremy Chase Crawford and E. Bridie Clemens and Thi H O Nguyen and Katherine Kedzierska and Nicole L. La Gruta and Philip Bradley and Paul G. Thomas},
  journal={Nature},
  year={2017},
  volume={547},
  pages={89-93}
}
T cells are defined by a heterodimeric surface receptor, the T cell receptor (TCR), that mediates recognition of pathogen-associated epitopes through interactions with peptide and major histocompatibility complexes (pMHCs). TCRs are generated by genomic rearrangement of the germline TCR locus, a process termed V(D)J recombination, that has the potential to generate marked diversity of TCRs (estimated to range from 1015 (ref. 1) to as high as 1061 (ref. 2) possible receptors). Despite this… CONTINUE READING

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