Quantal analysis of modulating action of adenosine on the mossy fiber synapse in hippocampal slices.

@article{Yamamoto1993QuantalAO,
  title={Quantal analysis of modulating action of adenosine on the mossy fiber synapse in hippocampal slices.},
  author={Chika Yamamoto and Satsuki Sawada and Takako Ohno-Shosaku},
  journal={Hippocampus},
  year={1993},
  volume={3 1},
  pages={87-92}
}
Although adenosine has been considered to depress release of neurotransmitter in central synapses, evidence for this notion is circumstantial. To obtain more direct and quantitative evidence, the suppressing action of adenosine on transmission through the mossy fiber synapse was examined by a quantal analysis in thin transverse sections of the guinea pig hippocampus. Adenosine suppressed excitatory postsynaptic potentials (EPSPs) induced in CA3 neurons by activation of single mossy fibers to 57… CONTINUE READING