Quantal Release of Serotonin

@article{Bruns2000QuantalRO,
  title={Quantal Release of Serotonin},
  author={Dieter Bruns and Dietmar Riedel and J{\"u}rgen Klingauf and Reinhard Jahn},
  journal={Neuron},
  year={2000},
  volume={28},
  pages={205-220}
}
We have studied the origin of quantal variability for small synaptic vesicles (SSVs) and large dense-cored vesicles (LDCVs). As a model, we used serotonergic Retzius neurons of leech that allow for combined amperometrical and morphological analyses of quantal transmitter release. We find that the transmitter amount released by a SSV varies proportionally to the volume of the vesicle, suggesting that serotonin is stored at a constant intravesicular concentration and is completely discharged… Expand
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