Quality of life in head and neck cancer patients: Impact of HPV and primary treatment modality

  title={Quality of life in head and neck cancer patients: Impact of HPV and primary treatment modality},
  author={Jessica H. Maxwell and Vikas Mehta and Hong Wang and Diana E. Cunningham and U. Duvvuri and Seungwon Kim and Jonas T. Johnson and Robert L Ferris},
  journal={The Laryngoscope},
To determine posttreatment quality of life (QOL) in head and neck cancer patients, stratifying by human papillomavirus (HPV)/p16 status and primary treatment modality. 

Long‐term quality of life in older patients with HPV‐related oropharyngeal cancer

This work explored if age affects quality of life (QOL) in survivors of locally advanced human papillomavirus (HPV)‐related oropharyngeal squamous cell carcinoma (SCC) and found no significant differences between the ages of patients with and without cancer.

A national study of health‐related quality of life in patients with cancer of the base of the tongue compared to the general population and to patients with tonsillar carcinoma

This exploratory, registry‐based, cross‐sectional study aimed to evaluate patients' health‐related quality of life (HRQOL) in a subsite of oropharyngeal cancer: cancer of the base of the tongue (CBT).

Considerations in Advanced and Recurrent Head and Neck Cancer

Head and neck cancer patients often present with more advanced disease than other cancer patients, and the disease process and its aggressive treatment modalities can impact several aspects of a patient’s quality of life.

Investigation of p16 status, chemotherapy regimen, and other nutrition markers for predicting gastrostomy in patients with head and neck cancer

The purpose of this study was to determine if p16 status, chemotherapy regimen, or other nutrition markers could improve protocol accuracy in predicting proactive gastrostomy in patients with head

Predicting two‐year longitudinal MD Anderson Dysphagia Inventory outcomes after intensity modulated radiotherapy for locoregionally advanced oropharyngeal carcinoma

To determine the factors associated with longitudinal patient‐reported dysphagia as measured by the MD Anderson Dysphagia Inventory (MDADI) in locoregionally advanced oropharyngeal carcinoma (OPC)

Influence of social factors on patient‐reported late symptoms: Report from a controlled trial among long‐term head and neck cancer survivors in Denmark

The incidence of head and neck cancer and morbidity and mortality after treatment are associated with social factors. Whether social factors also play a role in the prevalence of late‐onset symptoms

Tumor volume as a predictor of survival in human papillomavirus–positive oropharyngeal cancer

It has been observed that oropharyngeal squamous cell carcinoma in the setting of human papillomavirus (HPV) positivity have a greater propensity for cystic nodal metastases, and, thus, presumably larger volume with relatively smaller primary tumors.

Analysis of dysphagia in advanced-stage head-and-neck cancer patients: impact on quality of life and development of a preventive swallowing treatment

Dysphagia is both an acute-and-long-term side effect which greatly affects QoL of HNSCC patients undergoing multimodality treatment and a prophylactic swallowing program could actually produce a beneficial effect on patients’ outcomes.

Surviving Elderly Patients with Head-and-Neck Squamous Cell Carcinoma—What Is the Long-Term Quality of Life after Curative Radiotherapy?

Surviving elderly HNSCC patients treated by radiotherapy exhibit a relatively high long-term global QoL which is a relevant information for clinicians treating elderly H NSCC patients and for elderly patients themselves.

Evaluation, Prediction and Treatment of Radiation-Induced Normal Tissue Damage in Head and Neck Cancer

Locally advanced head and neck squamous cell cancer (HNSCC) requires a multidisciplinary approach and frequently concurrent chemoradiation (CRT) as a definitive or adjuvant treatment. Oral mucositis



Extracapsular spread in head and neck carcinoma: Impact of site and human papillomavirus status

The prognostic value of ECS in cervical lymph node metastases from head and neck squamous cell carcinoma was evaluated for patients with oropharyngeal SCC (OPC; with known p16/human papillomavirus [HPV] status) and for Patients with SCC of the oral cavity (OCC).

Chemoradiation in locally advanced head and neck cancer: new evidence, new challenges

  • J. Bernier
  • Medicine
    Expert review of anticancer therapy
  • 2004
Chemoradiation in locally advanced head and neck cancer: new evidence, new challenges, and new challenges.

Rising Incidence of Oropharyngeal Cancer and the Role of Oncogenic Human Papilloma Virus

Objectives/Hypothesis: To document the increasing incidence of oropharyngeal (OP) cancer and to provide evidence that this increase is caused by oncogenic human papilloma virus (HPV).

Brazilian–Portuguese validation of the University of Washington Quality of Life Questionnaire for patients with head and neck cancer

The University of Washington Quality of Life (UW‐QOL) questionnaire is an English‐language survey instrument used worldwide to assess the quality of life of patients with head and neck cancer. To be

Human Papillomavirus–Positive Oral Cavity and Oropharyngeal Cancer Patients Do Not Have Better Quality-of-Life Trajectories

  • Arun SharmaE. Mendez Chu Chen
  • Medicine
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • 2012
Among OSCC patients, high-risk HPV-associated tumors were associated with higher pretreatment QOL and a larger decrease in QOL from pretreatment to immediate posttreatment, suggesting that treatment intensity in this unique population may adversely affect QOL.

Transoral robotic surgery for oropharyngeal carcinoma and its impact on patient‐reported quality of life and function

The aim of this study was to assess the quality of life of patients with oropharyngeal squamous cell carcinoma after transoral robotic surgery (TORS).

Defining risk levels in locally advanced head and neck cancers: A comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501)

In 2004, level I evidence was established for the postoperative adjuvant treatment of patients with selected high‐risk locally advanced head and neck cancers, with the publication of the results of

Influences and predictors of long-term quality of life in head and neck cancer survivors.

Greater attention to these baseline predictors should be given when counseling patients about long-term function after treatment, as they appear to have strong influences on posttreatment QOL and have greater impact than treatment modality.

Comparison of human papillomavirus in situ hybridization and p16 immunohistochemistry in the detection of human papillomavirus‐associated head and neck cancer based on a prospective clinical experience

Human papillomavirus is a causative agent in a subset of head and neck squamous cell carcinomas that have a clinicopathologic profile that diverges from HPV‐negative HNSCCs, and testing may soon become integrated into standard pathologic assessment of HNSccs.

Transoral robotic surgery and human papillomavirus status: Oncologic results

Assessment of HPV‐related outcomes after transoral robotic surgery (TORS) with adjuvant therapy as indicated found patients with oropharyngeal squamous cell carcinoma have distinct outcome profiles based on their human papillomavirus (HPV) status.