Quality indicators increase the reliability of microarray data.

  title={Quality indicators increase the reliability of microarray data.},
  author={Wolfgang Raffelsberger and Doulaye Demb{\'e}l{\'e} and Mike G Neubauer and Marco M. Gottardis and Hinrich Gronemeyer},
  volume={80 4},
Large-scale gene expression profiling with DNA microarrays opens new dimensions to molecular biology but still lacks the overall precision of traditional low-scale techniques. We developed a novel strategy of data processing linking search stringency to quality indicators for efficient detection of low-level, regulated genes. Using retinoid-induced differentiation of NB-4 promyelocytic cells, the variation of expression profiles between biological duplicates was studied and compared with the… CONTINUE READING
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