Quality controls in cellular immunotherapies: rapid assessment of clinical grade dendritic cells by gene expression profiling.

@article{Castiello2013QualityCI,
  title={Quality controls in cellular immunotherapies: rapid assessment of clinical grade dendritic cells by gene expression profiling.},
  author={Luciano Castiello and Marianna Sabatino and Yingdong Zhao and Barbara Tumaini and Jiaqiang Ren and Jin Liang Ping and Ena Wang and Lauren V. Wood and Francesco M. Marincola and Raj K. Puri and David F Stroncek},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2013},
  volume={21 2},
  pages={476-84}
}
Cell-based immunotherapies are among the most promising approaches for developing effective and targeted immune response. However, their clinical usefulness and the evaluation of their efficacy rely heavily on complex quality control assessment. Therefore, rapid systematic methods are urgently needed for the in-depth characterization of relevant factors affecting newly developed cell product consistency and the identification of reliable markers for quality control. Using dendritic cells (DCs… CONTINUE READING