Quality by design approach for formulation, evaluation and statistical optimization of diclofenac-loaded ethosomes via transdermal route.

@article{Jain2015QualityBD,
  title={Quality by design approach for formulation, evaluation and statistical optimization of diclofenac-loaded ethosomes via transdermal route.},
  author={Shashank Jain and Niketkumar Patel and Parshotam L. Madan and Senshang Lin},
  journal={Pharmaceutical development and technology},
  year={2015},
  volume={20 4},
  pages={473-89}
}
The objective of this study was to fabricate and understand ethosomal formulations of diclofenac (DF) for enhanced anti-inflammatory activity using quality by design approach. DF-loaded ethosomal formulations were prepared using 4 × 5 full-factorial design with phosphatidylcholine:cholesterol (PC:CH) ratios ranging between 50:50 and 90:10, and ethanol concentration ranging between 0% and 30% as formulation variables. These formulations were characterized in terms of physicochemical properties… CONTINUE READING

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