Quality by design: understanding the formulation variables of a cyclosporine A self-nanoemulsified drug delivery systems by Box-Behnken design and desirability function.

@article{Zidan2007QualityBD,
  title={Quality by design: understanding the formulation variables of a cyclosporine A self-nanoemulsified drug delivery systems by Box-Behnken design and desirability function.},
  author={Ahmed Samir Zidan and Omaima Ahmed Sammour and Mohammed A. Hammad and Nagia A. Megrab and Muhammad J. Habib and Mansoor Ali Khan},
  journal={International journal of pharmaceutics},
  year={2007},
  volume={332 1-2},
  pages={
          55-63
        }
}
Quality by design (QBD) refers to the achievement of certain predictable quality with desired and predetermined specifications. A very useful component of the QBD is the understanding of factors and their interaction effects by a desired set of experiments. The present project deals with a case study to understand the effect of formulation variables of nanoemulsified particles of a model drug, cyclosporine A (CyA). A three-factor, three-level design of experiment (DOE) with response surface… Expand
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