Quality assessment and correlation of microsatellite instability and immunohistochemical markers among population- and clinic-based colorectal tumors results from the Colon Cancer Family Registry.

@article{iek2011QualityAA,
  title={Quality assessment and correlation of microsatellite instability and immunohistochemical markers among population- and clinic-based colorectal tumors results from the Colon Cancer Family Registry.},
  author={M Sertaç Çiçek and Noralane M. Lindor and Steven Gallinger and Bharati Bapat and John L. Hopper and Mark A Jenkins and Joanne P. Young and Daniel B Buchanan and M. D. Walsh and Lo{\"i}c Le Marchand and Terrilea Burnett and Polly A Newcomb and William M. Grady and Robert W Haile and Graham R Casey and Sarah J. Plummer and Lisa A Krumroy and John A. Baron and Stephen N. Thibodeau},
  journal={The Journal of molecular diagnostics : JMD},
  year={2011},
  volume={13 3},
  pages={271-81}
}
The detection of defective mismatch repair (MMR), as assessed by the presence of tumor microsatellite instability (MSI) and/or loss of MMR protein expression by IHC, has been useful for risk assessment, prognosis, and prediction of treatment in patients with colorectal cancer. We analyzed tumors for the presence of defective MMR from 5927 Colorectal Cancer Family Registry patients recruited at six international consortium sites. We evaluated the appropriate percentage instability cutoff used to… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

Similar Papers

Loading similar papers…