Quality and freshness of human bone marrow-derived mesenchymal stem cells decrease over time after trypsinization and storage in phosphate-buffered saline

@inproceedings{Shin2017QualityAF,
  title={Quality and freshness of human bone marrow-derived mesenchymal stem cells decrease over time after trypsinization and storage in phosphate-buffered saline},
  author={Tae Hwan Shin and Seungah Lee and Ki ryung Choi and Da Yeon Lee and Yongman Kim and Man Jeong Paik and Chan Hee Seo and Seok Ho Kang and Moon Suk Jin and Tae Hyeon Yoo and Seong Ho Kang and Gwang No Lee},
  booktitle={Scientific Reports},
  year={2017}
}
Human bone marrow-derived mesenchymal stem cells (hBM-MSCs) have been studied for their therapeutic potential. However, evaluating the quality of hBM-MSCs before transplantation remains a challenge. We addressed this issue in the present study by investigating deformation, the expression of genes related to reactive oxygen species (ROS) generation, changes in amino acid profiles, and membrane fluidity in hBM-MSCs. Deformability and cell size were decreased after storage for 6 and 12 h… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 46 references

Advances in the Treatment of Ischemic Diseases by Mesenchymal Stem Cells

S Li
Stem Cells Int 2016, • 2016

Phase 2 Trial

Suk, K. T. et al. Transplantation with Autologous Bone Mar Cirrhosis
Hepatology 64, 2185–2197, doi:10.1002/hep.v64.6 • 2016

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