Qualitative studies on the metabolism and the toxicological detection of the fentanyl-derived designer drugs 3-methylfentanyl and isofentanyl in rats using liquid chromatography–linear ion trap–mass spectrometry (LC-MSn)

@article{Meyer2011QualitativeSO,
  title={Qualitative studies on the metabolism and the toxicological detection of the fentanyl-derived designer drugs 3-methylfentanyl and isofentanyl in rats using liquid chromatography–linear ion trap–mass spectrometry (LC-MSn)},
  author={M. Meyer and J. Dinger and Andrea E. Schwaninger and D. Wissenbach and J. Zapp and G. Fritschi and H. Maurer},
  journal={Analytical and Bioanalytical Chemistry},
  year={2011},
  volume={402},
  pages={1249-1255}
}
  • M. Meyer, J. Dinger, +4 authors H. Maurer
  • Published 2011
  • Chemistry, Medicine
  • Analytical and Bioanalytical Chemistry
    • The opioid 3-methylfentanyl, a designer drug of the fentanyl type, was scheduled by the Controlled Substance Act due to its high potency and abuse potential. To overcome this regulation, isofentanyl, another designer fentanyl, was synthesized in a clandestine laboratory and seized by the German police. The aims of the presented study were to identify the phase I and phase II metabolites of 3-methylfentanyl and isofentanyl in rat urine, to identify the cytochrome P450 (CYP) isoenzymes involved… CONTINUE READING
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    References

    SHOWING 1-10 OF 17 REFERENCES
    Studies on the metabolism of the α-pyrrolidinophenone designer drug methylenedioxy-pyrovalerone (MDPV) in rat and human urine and human liver microsomes using GC-MS and LC-high-resolution MS and its detectability in urine by GC-MS.
    • 169
    A comprehensive LC-MS-based quantitative analysis of fentanyl-like drugs in plasma and urine.
    • 30
    Studies on 1-(2-Phenethyl)-4-(N-Propionylanilino)Piperidine (Fentanyl) and Its Related Compounds: Novel Metabolites in Rat Urine Following Injection of α-Methylfentanyl, One of the Most Abused Typical Designer Drugs
    • 11
    • PDF
    Enantioselectivity in the methylation of the catecholic phase I metabolites of methylenedioxy designer drugs and their capability to inhibit catechol-O-methyltransferase-catalyzed dopamine 3-methylation.
    • 40
    Metabolism of fentanyl, a synthetic opioid analgesic, by human liver microsomes. Role of CYP3A4.
    • D. Feierman, J. Lasker
    • Chemistry, Medicine
    • Drug metabolism and disposition: the biological fate of chemicals
    • 1996
    • 142
    Drugs of abuse screening in urine as part of a metabolite-based LC-MSn screening concept
    • 119
    Development of the first metabolite-based LC-MSn urine drug screening procedure-exemplified for antidepressants
    • 101
    • PDF
    Studies on 1-(2-phenethyl)-4-(N-propionylanilino)piperidine (fentanyl) and its related compounds. VI. Structure-analgesic activity relationship for fentanyl, methyl-substituted fentanyls and other analogues
    • 101
    Mass spectral and GC data of drugs, poisons, pesticides, pollutants and their metabolites: Part 3 mass spectra (m/z222 to 777 amu).
    • 259
    • PDF
    Possible involvement of multiple cytochrome P450S in fentanyl and sufentanil metabolism as opposed to alfentanil.
    • 74