Qualitative studies on the metabolism and the toxicological detection of the fentanyl-derived designer drugs 3-methylfentanyl and isofentanyl in rats using liquid chromatography–linear ion trap–mass spectrometry (LC-MSn)

@article{Meyer2011QualitativeSO,
  title={Qualitative studies on the metabolism and the toxicological detection of the fentanyl-derived designer drugs 3-methylfentanyl and isofentanyl in rats using liquid chromatography–linear ion trap–mass spectrometry (LC-MSn)},
  author={M. Meyer and J. Dinger and Andrea E. Schwaninger and D. Wissenbach and J. Zapp and G. Fritschi and H. Maurer},
  journal={Analytical and Bioanalytical Chemistry},
  year={2011},
  volume={402},
  pages={1249-1255}
}
  • M. Meyer, J. Dinger, +4 authors H. Maurer
  • Published 2011
  • Chemistry, Medicine
  • Analytical and Bioanalytical Chemistry
  • The opioid 3-methylfentanyl, a designer drug of the fentanyl type, was scheduled by the Controlled Substance Act due to its high potency and abuse potential. To overcome this regulation, isofentanyl, another designer fentanyl, was synthesized in a clandestine laboratory and seized by the German police. The aims of the presented study were to identify the phase I and phase II metabolites of 3-methylfentanyl and isofentanyl in rat urine, to identify the cytochrome P450 (CYP) isoenzymes involved… CONTINUE READING
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