Qualitative studies on the metabolism and the toxicological detection of the fentanyl-derived designer drugs 3-methylfentanyl and isofentanyl in rats using liquid chromatography–linear ion trap–mass spectrometry (LC-MSn)

@article{Meyer2011QualitativeSO,
  title={Qualitative studies on the metabolism and the toxicological detection of the fentanyl-derived designer drugs 3-methylfentanyl and isofentanyl in rats using liquid chromatography–linear ion trap–mass spectrometry (LC-MSn)},
  author={Markus R. Meyer and Julia Dinger and Andrea E. Schwaninger and Dirk K. Wissenbach and Josef Zapp and Giselher Fritschi and Hans H. Maurer},
  journal={Analytical and Bioanalytical Chemistry},
  year={2011},
  volume={402},
  pages={1249-1255}
}
The opioid 3-methylfentanyl, a designer drug of the fentanyl type, was scheduled by the Controlled Substance Act due to its high potency and abuse potential. To overcome this regulation, isofentanyl, another designer fentanyl, was synthesized in a clandestine laboratory and seized by the German police. The aims of the presented study were to identify the phase I and phase II metabolites of 3-methylfentanyl and isofentanyl in rat urine, to identify the cytochrome P450 (CYP) isoenzymes involved… 

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In vitro metabolism of the novel synthetic opioid agonist cyclopropylfentanyl and subsequent confirmation in authentic human samples using liquid chromatography-high resolution mass spectrometry.

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In vitro and in vivo metabolite identification studies for new fentanyl analogs matched the in vivo findings well, showing identical biotransformations in each system, and suggest the following specific and abundant metabolites as analytical targets in urine.

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