Qualitative simulation of the initiation of sporulation in Bacillus subtilis.

  title={Qualitative simulation of the initiation of sporulation in Bacillus subtilis.},
  author={Hidde de Jong and Johannes Geiselmann and Gr{\'e}gory Batt and C{\'e}line Hernandez and Michel Page},
  journal={Bulletin of mathematical biology},
  volume={66 2},
Under conditions of nutrient deprivation, the Gram positive soil bacterium Bacillus subtilis can abandon vegetative growth and form a dormant, environmentally-resistant spore instead. The decision to either divide or sporulate is controlled by a large and complex genetic regulatory network integrating various environmental, cell-cycle, and metabolic signals. Although sporulation in B. subtilis is one of the best-understood model systems for prokaryotic development, very little quantitative data… CONTINUE READING

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