Qualitative determination of synthetic analogues of insulin in human plasma by immunoaffinity purification and liquid chromatography-tandem mass spectrometry for doping control purposes.

@article{Thevis2005QualitativeDO,
  title={Qualitative determination of synthetic analogues of insulin in human plasma by immunoaffinity purification and liquid chromatography-tandem mass spectrometry for doping control purposes.},
  author={Mario Thevis and Andreas Thomas and Philippe Delahaut and Alain Bosseloir and Wilhelm Schaenzer},
  journal={Analytical chemistry},
  year={2005},
  volume={77 11},
  pages={3579-85}
}
Synthetic insulins such as Humalog Lispro, Novolog Aspart, or Lantus Glargine, are commonly employed for the treatment of insulin-dependent diabetes mellitus owing to convenient handling and fast or prolonged bioavailability. However, the misuse of insulin in sports has been reported often, and the international doping control system requires a reliable and robust assay to determine the presence or absence of related drugs prohibited by the World Anti-Doping Agency. Qualitative evidence of… CONTINUE READING
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