Qualitative and quantitative studies of heparin and chondroitin sulfates in normal human plasma.

@article{Volpi1995QualitativeAQ,
  title={Qualitative and quantitative studies of heparin and chondroitin sulfates in normal human plasma.},
  author={Nicola Volpi and M Cusmano and T Venturelli},
  journal={Biochimica et biophysica acta},
  year={1995},
  volume={1243 1},
  pages={
          49-58
        }
}
Heparin was extracted and purified from normal human plasma, and full characterization of its structure and physico-chemical properties was achieved for the first time. Plasma was submitted to exhaustive proteolytic treatment with papain, trypsin, chymotrypsin, collagenase and pepsin, anion-exchange chromatography and precipitation with organic solvents. By this procedure, we recovered heparin (about 0.7 mg/100 ml of plasma) and chondroitin sulfate (about 0.1 mg/100 ml of plasma). Chondroitin… CONTINUE READING
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