Qualitative and quantitative effects on epidermal Langerhans (Ia+) and Thy-1+ dendritic cells following topical application of phorbol diesters and mezerein.

@article{Baxter1988QualitativeAQ,
  title={Qualitative and quantitative effects on epidermal Langerhans (Ia+) and Thy-1+ dendritic cells following topical application of phorbol diesters and mezerein.},
  author={C. Stuart Baxter and K Chalfin and Anastasia Andringa and Marian L Miller},
  journal={Carcinogenesis},
  year={1988},
  volume={9 9},
  pages={1563-8}
}
Repeated twice-weekly applications of promoting doses of 12-O-tetradecanoylphorbol-13-acetate (TPA) to the dorsal skin of female adult SENCAR mice led to a reduction in numbers per unit area of epidermal Thy-1+ dendritic cells. Although no parallel effect was observed on Ia+ Langerhans cells, a concurrent reduction of dendritic morphology of both cell types… CONTINUE READING