Qualitative and quantitative detection of mitochondrial heteroplasmy in cerebrospinal fluid using denaturing high-performance liquid chromatography.

@article{Conley2003QualitativeAQ,
  title={Qualitative and quantitative detection of mitochondrial heteroplasmy in cerebrospinal fluid using denaturing high-performance liquid chromatography.},
  author={Yvette P. Conley and Heather Marie Brockway and M. E. Beatty and Mary E. Kerr},
  journal={Brain research. Brain research protocols},
  year={2003},
  volume={12 2},
  pages={99-103}
}
Detecting and quantifying generalized mitochondrial heteroplasmy is essential if the field of mitochondrial genetics is to advance in the arena of complex genetic disorders. The majority of techniques used to detect and quantify mitochondrial heteroplasmy focus on a known mutation or polymorphism. The necessity of knowing the mitochondrial DNA (mtDNA) change beforehand means that non-specific heteroplasmy in general cannot be assessed. In this study, we assessed the extent that denaturing high… CONTINUE READING

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