Qualifying for the license to replicate

@article{Su1995QualifyingFT,
  title={Qualifying for the license to replicate},
  author={Tin Tin Su and Peter J. Follette and Patrick H O'Farrell},
  journal={Cell},
  year={1995},
  volume={81},
  pages={825-828}
}
A single replication fork would take more than a year to replicate the genome of Xenopus. By dividing the task among many thousands of replicons, each replicated by forks emanating from individual origins, replication is instead completed in as little as 30 min. While this efficient strategy has been adopted by all eukaryotes, it introduces a complication. To maintain the integrity of the genome, multiple replicons must now be coordinated so that all sequences are replicated exactly once per… CONTINUE READING

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