QualComp: a new lossy compressor for quality scores based on rate distortion theory

@inproceedings{Ochoa2012QualCompAN,
  title={QualComp: a new lossy compressor for quality scores based on rate distortion theory},
  author={Idoia Ochoa and Himanshu Asnani and Dinesh Bharadia and Mainak Chowdhury and Tsachy Weissman and Golan Yona},
  booktitle={BMC Bioinformatics},
  year={2012}
}
Next Generation Sequencing technologies have revolutionized many fields in biology by reducing the time and cost required for sequencing. As a result, large amounts of sequencing data are being generated. A typical sequencing data file may occupy tens or even hundreds of gigabytes of disk space, prohibitively large for many users. This data consists of both the nucleotide sequences and per-base quality scores that indicate the level of confidence in the readout of these sequences. Quality… CONTINUE READING
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