Quaking, an RNA-binding protein, is a critical regulator of vascular smooth muscle cell phenotype.

  title={Quaking, an RNA-binding protein, is a critical regulator of vascular smooth muscle cell phenotype.},
  author={Eric P. van der Veer and Ruben G de Bruin and Adriaan O. Kraaijeveld and Amanda Pronk and Ilze Bot and T. P{\'e}ra and Filip M. Segers and Stella Trompet and Janine M. van Gils and Marko K. Roeten and Cora M. L. Beckers and Peter J. van Santbrink and Anique Janssen and Coen van Solingen and Jim Swildens and Hetty C. de Boer and Erna A. B. Peters and Roel Bijkerk and M M J Rousch and Merijn Doop and J. J. W. Kuiper and Martin Jan Schalij and Allard C. van der Wal and St{\'e}phane Richard and Theo J. C. van Berkel and J. Geoffrey Pickering and Pieter S Hiemstra and Marie Jose T. H. Goumans and Ton J Rabelink and Antoine A. F. de Vries and Paul H. A. Quax and Jan Wouter Jukema and Erik A. L. Biessen and Anton Jan van Zonneveld},
  journal={Circulation research},
  volume={113 9},
RATIONALE RNA-binding proteins are critical post-transcriptional regulators of RNA and can influence pre-mRNA splicing, RNA localization, and stability. The RNA-binding protein Quaking (QKI) is essential for embryonic blood vessel development. However, the role of QKI in the adult vasculature, and in particular in vascular smooth muscle cells (VSMCs), is currently unknown. OBJECTIVE We sought to determine the role of QKI in regulating adult VSMC function and plasticity. METHODS AND RESULTS… CONTINUE READING
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