Quadruplex-forming oligonucleotide targeted to the VEGF promoter inhibits growth of non-small cell lung cancer cells

@inproceedings{Muench2019QuadruplexformingOT,
  title={Quadruplex-forming oligonucleotide targeted to the VEGF promoter inhibits growth of non-small cell lung cancer cells},
  author={David E Muench and Francine Rezzoug and Shelia D Thomas and Jingjing Xiao and A B M Saiful Islam and Donald M Miller and Kara C. Sedoris},
  booktitle={PloS one},
  year={2019}
}
BACKGROUND Vascular endothelial growth factor (VEGF) is commonly overexpressed in a variety of tumor types including lung cancer. As a key regulator of angiogenesis, it promotes tumor survival, growth, and metastasis through the activation of the downstream protein kinase B (AKT) and extracellular signal-regulated kinase (ERK 1/2) activation. The VEGF promoter contains a 36 bp guanine-rich sequence (VEGFq) which is capable of forming quadruplex (four-stranded) DNA. This sequence has been… CONTINUE READING

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