Quadruplex formation is necessary for stable PNA invasion into duplex DNA of BCL2 promoter region

@inproceedings{Onyshchenko2011QuadruplexFI,
  title={Quadruplex formation is necessary for stable PNA invasion into duplex DNA of BCL2 promoter region},
  author={Mykola I. Onyshchenko and Timur I. Gaynutdinov and Ethan A. Englund and Daniel H. Appella and Ronald D. Neumann and Igor G. Panyutin},
  booktitle={Nucleic acids research},
  year={2011}
}
Guanine-rich sequences are highly abundant in the human genome, especially in regulatory regions. Because guanine-rich sequences have the unique ability to form G-quadruplexes, these structures may play a role in the regulation of gene transcription. In previous studies, we demonstrated that formation of G-quadruplexes could be induced with peptide nucleic acids (PNAs). PNAs designed to bind the C-rich strand upstream of the human BCL2 gene promoted quadruplex formation in the complementary G… CONTINUE READING

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