Quadruplex formation by a guanine-rich PNA oligomer.

  title={Quadruplex formation by a guanine-rich PNA oligomer.},
  author={Bhaskar Datta and Mark E Bier and Subhadeep Roy and Bruce A Armitage},
  journal={Journal of the American Chemical Society},
  volume={127 12},
A guanine-rich PNA dodecamer having the sequence H-G4T4G4-Lys-NH2 (G-PNA) hybridizes with a DNA dodecamer of homologous sequence to form a four-stranded quadruplex (Datta, B.; Schmitt, C.; Armitage, B. A. J. Am. Chem. Soc. 2003, 125, 4111-4118). This report describes quadruplex formation by the PNA alone. UV melting curves and fluorescence resonance energy transfer experiments reveal formation of a multistranded structure stabilized by guanine tetrads. The ion dependency of these structures is… CONTINUE READING