Quad screen as a predictor of adverse pregnancy outcome.


OBJECTIVE To estimate the effect of second-trimester levels of maternal serum alpha-fetoprotein (AFP), human chorionic gonadotrophin (hCG), unconjugated estriol (uE3), and inhibin A (the quad screen) on obstetric complications by using a large, prospectively collected database (the FASTER database). METHODS The FASTER trial was a multicenter study that evaluated first- and second-trimester screening programs for aneuploidy in women with singleton pregnancies. As part of this trial, patients had a quad screen drawn at 15-18 6/7 weeks. We analyzed the data to identify associations between the quad screen markers and preterm birth, intrauterine growth restriction, preeclampsia, and fetal loss. Our analysis was performed by evaluating the performance characteristics of quad screen markers individually and in combination. Crude and adjusted effects were estimated by multivariable logistic regression analysis. Patients with fetal anomalies were excluded from the analysis. RESULTS We analyzed data from 33,145 pregnancies. We identified numerous associations between the markers and the adverse outcomes. There was a relatively low, but often significant, risk of having an adverse pregnancy complication if a patient had a single abnormal marker. However, the risk of having an adverse outcome increased significantly if a patient had 2 or more abnormal markers. The sensitivity and positive predictive values using combinations of markers is relatively low, although superior to using individual markers. CONCLUSION These data suggest that components of the quad screen may prove useful in predicting adverse obstetric outcomes. We also showed that the total number and specific combinations of abnormal markers are most useful in predicting the risk of adverse perinatal outcome.

Citations per Year

1,982 Citations

Semantic Scholar estimates that this publication has 1,982 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Dugoff2005QuadSA, title={Quad screen as a predictor of adverse pregnancy outcome.}, author={Lorraine Dugoff and John C. Hobbins and Fergal Desmond Malone and John Vidaver and Lisa Sullivan and Jacob A. Canick and Geralyn M Lambert-Messerlian and Timothy F. Porter and David Luthy and Christine H. Comstock and George R. Saade and Keith A Eddleman and Irwin R. Merkatz and Sabrina D. Craigo and I E Timor-Tritsch and Stephen R. Carr and Honor M. Wolfe and Mary E D'alton}, journal={Obstetrics and gynecology}, year={2005}, volume={106 2}, pages={260-7} }