QuShape: rapid, accurate, and best-practices quantification of nucleic acid probing information, resolved by capillary electrophoresis.

@article{Karabiber2013QuShapeRA,
  title={QuShape: rapid, accurate, and best-practices quantification of nucleic acid probing information, resolved by capillary electrophoresis.},
  author={Fethullah Karabiber and Jennifer L McGinnis and Oleg Vyacheslavovich Favorov and Kevin M Weeks},
  journal={RNA},
  year={2013},
  volume={19 1},
  pages={63-73}
}
Chemical probing of RNA and DNA structure is a widely used and highly informative approach for examining nucleic acid structure and for evaluating interactions with protein and small-molecule ligands. Use of capillary electrophoresis to analyze chemical probing experiments yields hundreds of nucleotides of information per experiment and can be performed on automated instruments. Extraction of the information from capillary electrophoresis electropherograms is a computationally intensive… CONTINUE READING
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Fingerprinting non-canonical and tertiary RNA structures by differential SHAPE reactivity

  • Steen K-A, GM Rice, Weeks KM.
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