QscR-mediated transcriptional activation of serine cycle genes in Methylobacterium extorquens AM1.

@article{Kalyuzhnaya2005QscRmediatedTA,
  title={QscR-mediated transcriptional activation of serine cycle genes in Methylobacterium extorquens AM1.},
  author={Marina G. Kalyuzhnaya and Mary E. Lidstrom},
  journal={Journal of bacteriology},
  year={2005},
  volume={187 21},
  pages={7511-7}
}
QscR, a LysR-type regulator, is the major regulator of assimilatory C1 metabolism in Methylobacterium extorquens AM1. It has been shown to interact with the promoters of the two operons that encode the majority of the serine cycle enzymes (sga-hpr-mtdA-fch for the qsc1 operon and mtkA-mtkB-ppc-mclA for the qsc2 operon), as well as with the promoter of glyA and its own promoter. To obtain further insights into the mechanisms of this regulation, we mapped transcriptional start sites for the qsc1… CONTINUE READING

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