Qri7/OSGEPL, the mitochondrial version of the universal Kae1/YgjD protein, is essential for mitochondrial genome maintenance

@inproceedings{Oberto2009Qri7OSGEPLTM,
  title={Qri7/OSGEPL, the mitochondrial version of the universal Kae1/YgjD protein, is essential for mitochondrial genome maintenance},
  author={Jacques Oberto and Norman Breuil and Arnaud Hecker and Francesca Farina and C{\'e}line Brochier-Armanet and Emmanuel Culetto and Patrick Forterre},
  booktitle={Nucleic acids research},
  year={2009}
}
Yeast Qri7 and human OSGEPL are members of the orthologous Kae1(OSGEP)/YgjD protein family, the last class of universally conserved proteins without assigned function. Phylogenetic analyses indicate that the eukaryotic Qri7(OSGEPL) proteins originated from bacterial YgjD proteins. We have recently shown that the archaeal Kae1 protein is a DNA-binding protein that exhibits apurinic endonuclease activity in vitro. We show here that the Qri7/OSGEPL proteins localize in mitochondria and are… CONTINUE READING
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