Qo site of mitochondrial complex III is the source of increased superoxide after transient exposure to hydrogen peroxide.


Transient exposure of cardiac myocytes to hydrogen peroxide (H(2)O(2)) results in further production of superoxide by the mitochondria as a result of increased influx of calcium through the L-type Ca(2+) channel and increased calcium uptake by the mitochondria. The response persists as a result of positive feedback on the channel and induces alterations in… (More)
DOI: 10.1016/j.yjmcc.2010.07.015


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