QacR Is a Repressor Protein That Regulates Expression of theStaphylococcus aureus Multidrug Efflux Pump QacA*

  title={QacR Is a Repressor Protein That Regulates Expression of theStaphylococcus aureus Multidrug Efflux Pump QacA*},
  author={Steve Grkovic and Melissa H. Brown and Natalie J. Roberts and Ian T. Paulsen and Ronald A. Skurray},
  journal={The Journal of Biological Chemistry},
  pages={18665 - 18673}
The Staphylococcus aureus QacA protein is a multidrug transporter that confers resistance to a broad range of antimicrobial agents via proton motive force-dependent efflux of the compounds. Primer extension analysis was performed to map the transcription start points of theqacA and divergently transcribed qacRmRNAs. Each gene utilized a single promoter element, the locations of which were confirmed by site-directed mutagenesis. Fusions of theqacA and qacR promoters to a chloramphenicol acetyl… 

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