QX-314 produces long-lasting local anesthesia modulated by transient receptor potential vanilloid receptors in mice.

@article{Ries2009QX314PL,
  title={QX-314 produces long-lasting local anesthesia modulated by transient receptor potential vanilloid receptors in mice.},
  author={Craig R. Ries and Ray Pillai and Cheryl C. W. Chung and Jimmy Tanche Wang and Bernard A. MacLeod and Stephan K. W. Schwarz},
  journal={Anesthesiology},
  year={2009},
  volume={111 1},
  pages={
          122-6
        }
}
BACKGROUND The quaternary lidocaine derivative QX-314 is now known to produce long-lasting local anesthesia despite its positive charge. However, recent research suggests that the transient receptor potential vanilloid receptor agonist, capsaicin, should reduce the onset and offset times, whereas the transient receptor potential vanilloid receptor antagonist, capsazepine, should delay the onset time of sensory blockade by QX-314. METHODS Sensory blockade in the tail of the conscious mouse was… CONTINUE READING
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