QUIT: QUantitative Imaging Tools

  title={QUIT: QUantitative Imaging Tools},
  author={Tobias C Wood},
  journal={Journal of Open Source Software},
  • Tobias C Wood
  • Published 21 June 2018
  • Journal of Open Source Software
MICRA: Microstructural image compilation with repeated acquisitions
Age-Specific Adult Rat Brain MRI Templates and Tissue Probability Maps
A set of rat brain templates and tissue probability maps from across the adult lifespan is released to expand the preclinical MRI community's fundamental resources.
Rapid parameter estimation for selective inversion recovery myelin imaging using an open-source Julia toolkit
A fast, open-source toolkit for processing quantitative magnetization transfer derived from selective inversion recovery (SIR) acquisitions that allows parameter map estimation, including the myelin-sensitive macromolecular pool size ratio (PSR).
In vivo multi-parametric manganese-enhanced MRI for detecting amyloid plaques in rodent models of Alzheimer’s disease
The first in vivo evidence of manganese as a potential targeted contrast agent for imaging plaques in the 5xFAD model of AD is presented, and Manganese-induced signal enhancement can enable higher-resolution imaging, which is key to visualizing these small amyloid deposits.
Fast calculation software for modified Look-Locker inversion recovery (MOLLI) T1 mapping
The presented software tool (fT1fit) facilitated rapid T1 map and extracellular volume fraction map calculations and the C++ multi-core RD was the fastest method on a regular eight-core personal computer for pre- or post-contrast T1map calculation.
Peripheral inflammation is associated with micro-structural and functional connectivity changes in depression-related brain networks
Depression was associated with reduced weighted degree of pC/pCC, mPFC, and other nodes of the default mode network (DMN), and CRP-related increases in proton density—a plausible marker of extracellular oedema—and changes in functional connectivity were anatomically co-localised with DMN nodes that also demonstrated significantly reduced hubness in depression.
The innate immune toll-like-receptor-2 modulates the depressogenic and anorexiolytic neuroinflammatory response in obstructive sleep apnoea
By utilising multimodal imaging in this established model of OSA, a discernible neuroinflammatory response was demonstrated for the first time and the modulatory role for the functional TLR2-system was suggested in aetiology of depressive, anxious and anorexiolytic symptoms in OSA.
Silent T1 mapping using the variable flip angle method with B1 correction
To compare the silent rotating ultrafast imaging sequence (RUFIS) to a traditional Cartesian spoiled gradient‐echo (SPGR) acquisition scheme for variable flip angle (VFA) T1 mapping.
Magnetization transfer and frequency distribution effects in the SSFP ellipse
To demonstrate that quantitative magnetization transfer parameters can be extracted from steady‐state free‐precession (SSFP) data with no external T1 map or banding artifacts, data from three consecutive SSFP studies are analyzed.


An investigation of regional cerebral blood flow and tissue structure changes after acute administration of antipsychotics in healthy male volunteers
It is illustrated that a single clinically relevant oral dose of an antipsychotic has no detectable acute effect on T1 in healthy volunteers, and a methodology for applying quantitative imaging methods to assess the acute effects of other compounds on structural MRI metrics is provided.
Genome-Wide Transcriptional Profiling and Structural Magnetic Resonance Imaging in the Maternal Immune Activation Model of Neurodevelopmental Disorders
It is demonstrated that prenatal viral-like immune activation causes myelin-related transcriptional and epigenetic changes in corticostriatal areas of adult offspring exposed to prenatal immune activation.
Whole-brain ex-vivo quantitative MRI of the cuprizone mouse model
The whole brain of the cuprizone mouse ex-vivo is imaged and analyzed using high-resolution quantitative MR methods and changes in multiple regions are found, including the corpus callosum, cerebellum, thalamus and hippocampus.