QUALITY OF LIFE ON ANGINA THERAPY: A RANDOMISED CONTROLLED TRIAL OF TRANSDERMAL GLYCERYL TRINITRATE AGAINST PLACEBO

@article{Fletcher1988QUALITYOL,
  title={QUALITY OF LIFE ON ANGINA THERAPY: A RANDOMISED CONTROLLED TRIAL OF TRANSDERMAL GLYCERYL TRINITRATE AGAINST PLACEBO},
  author={Astrid Elizabeth Fletcher and Philip McLoone and Christopher John Bulpitt},
  journal={The Lancet},
  year={1988},
  volume={332},
  pages={4-8}
}
In a randomised controlled trial in 427 men with chronic stable angina continuous use of 5 mg transdermal glyceryl trinitrate (GTN) showed no advantage over placebo in terms of efficacy (anginal attack rates and sublingual GTN consumption) or quality of life (as measured with the sickness impact profile and a health index of disability). Patients on the active drug reported headaches more frequently than patients on placebo, and a higher proportion of them withdrew from the trial because of… CONTINUE READING
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